Central Nervous System Complications in Allogeneic Stem Cell Transplantation.
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概要
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Central nervous system (CNS) complications in stem cell transplantation are a serious problem and likely influence mortality. However, their prevention, early diagnosis, and treatment remain to be solved. In order to clarify CNS complications, we analyzed 97 patients who underwent allogeneic stem cell transplantation at our institute over the past 5 years. Thirteen patients developed neurologic complications. Those were 2 cases of intracranial hemorrhage, infarction and leukoencephalopathy in each ; and one case each of subaracnoid hemorrhage, subdural hemorrhage, hemorrhagic infarction and previous infarction ;and three normal cases from radiographic findings. According to the preconditioning regimen, the incidence of CNS complications was 3/47 (6%) in the standard-risk regimen and 10/56 (18%) in the high-risk regimen. It was 7/89 (8%) among patients with mild GVHD (≤II) and 6/14 (43%) among severe cases (III≤). The outcome was very poor, with only 5 patients surviving. To decrease the incidence of CNS complications, we need to clarify the risk factors that may help to establish a useful method of prevention, early diagnosis, and treatment.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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