Role of Alloreactive Cytotoxic T Lymphocytes in Cord Blood Stem Cell Transplantation.
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In patients who developed graft-vs-host disease following allogeneic bone marrow transplantation, the incidence of leukemia relapse is decreased as a result of the graft-vs-leukemia (GVL) effect. In cord blood stem cell transplantation, it is not known if the GVL effect exists. We have investigated the possibility of generating cytotoxic T lymphocytes (CTL) in a mixed lymphocyte culture (MLC). The MLC was set up using cord blood mononuclear cells as responders and the irradiated mononuclear cells of a healthy adult as stimulators. After seven days, the CTL activity was measured. In 17 out of 20 cord blood samples, alloreactive CTL was generated. A simultaneous flow cytometric analysis revealed that CD8+CD45RO+ cells markedly increased following MLC. These <I>in vitro</I> results suggest that the GVL effect may operate <I>in vivo</I> in cord blood stem cell transplantation
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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