HLA 1-Locus Mismatched Umbilical Cord Blood Transplantation for a Child with Acute Monocytic Leukemia (M5) in the First Complete Remission.
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We present the case of a 21-month-old girl with infantile leukemia who received a 1-locus mismatched umbilical cord blood transplant from her sister. The patient suffered from acute monocytic leukemia (AMoL) with poor prognostic factors, including abnormal 11q23 translocation and CNS-leukemia since the age of four months. After induction chemotherapy, she entered complete remission (CR), and remained in CR until the cord blood transplant. We collected 75 ml of cord blood from her sister, which contained 2.8 × 10<SUP>7</SUP>/kg of mononuclear cells (8.4 × 10<SUP>4</SUP>/kg of CD34 positive cells). The preconditioning regimen consisted of busulfan 35 mg/m<SUP>2</SUP>×4/day for four days and melphalan 70 mg/m<SUP>2</SUP>/day for three days. No graft-versus-host disease (GVHD) prophylaxis was performed. A hematological engraftment was sustained with white blood cell counts > 1, 000/μl on day 12, neotrophil counts > 500/μl on day 13, and platelet counts > 50, 000/μl on day 43.We recognized her HLA type changed to the donor's type on day 22. Although grade II GVHD had occurred, she responded well to methyl prednisolone pulse therapy and cyclosporin A. At nine months post-transplant, she remains in CR without evidence of chronic GVHD.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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