Two Cases of Hemophilia A with Inhibitor, Treated with Induction of Immune Tolerance by Factor VIII.
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We report our experience of induction of immune tolerance by factor VIII in low or intermediate dose carried out on 2 hemophiliacs A with inhibitor. Case 1, an 11-month-old boy, high responder (inhibitor level 48 Bethesda units), had been treated with factor VIII at 500 units (60 units/kg) ×3times/week. In the 10th week of treatment, his inhibitor level was increased to 78 Bethesda units but it was decreased to 11 Bethesda units in the 68th week. Case 2, a 20-year-old man, low responder (inhibitor level 0.9 Bethesda units), suffered from left iliopsoas hematoma. He had been treated with factor VIII at 6, 000 units (74 units/kg) /day×10 days and 3, 000 units/day×14 days. His inhibitor level was increased to 1.8 Bethesda units after treatment, but it had decreased to less than 0.5 Bethesda units 2 years later. We recommend this treatment for hemophiliacs with inhibitors for both cost and safety reasons.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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