Expression and Function of Tumor Necrosis Factor-.ALPHA. Receptor of Leukemic Cells.
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Expression of tumor necrosis factor-receptor (TNF-R) was studied using flow cytometry. Both TNF-Rp55 and TNF-Rp75 were expressed on peripheral T cells, B cells and granulocytes. Monocytes expressed TNF-Rp75 alone. Both types of TNF-R were significantly up-regulated on IL-2-activated T cells. TNF-Rp55 and TNF-Rp75 were detected on leukemic cells from 42 of 51 cases and from 32 of 51 cases, respectively. We also demonstrated that TNF-α induced significant inhibition of DNA synthesis in 9 of 12 ALL cases. In contrast, response of ANLL was more variable. Inhibition of DNA synthesis was induced in 9 of 17 ANLL cases, whereas TNF-α enhanced DNA synthesis in 2 ANLL cases. It was suggested that TNF-α could trigger inhibitory signals mainly through TNF-Rp55 because : 1) TNF-α-induced inhibitory effect on DNA synthesis could be observed in leukemic cells, which expressed TNF-Rp55 alone, and 2) blocking antibodies against TNF-Rp75 could not restore the inhibition of DNA synthesis triggered by TNF-α at all.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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