最近10年間のA群溶連菌感染症と分離菌の血清型・薬剤感受性

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Six hundred and seventy isolates from children with group A streptococcal infections from 1981 through 1990 were typed serologically and their antibiotic susceptibilities were determined. Productivity of streptococcal pyrogenic exotoxins was also investigated in some isolates. Four hundred and seventy-nine strains were isolated from patients with pharyngitis, 133 from those with scarlet fever, 35 from those with suppurative infection and 23 from those with nonsuppurative disease. With immediate treatment (antibiotics were started at the same day throat swabs were taken) for 10 days, 5.3% of the patients with pharyngitis including scarlet fever had relapses and 13.4% of those patients had recurrences. Of the episodes of recurrences 15.7% were due to the same M serotype strains. Six patients had two episodes of scarlet fever. M type of isolate was different in the first and the second episode of each patient. Pyrogenic exotoxin type was unprecedented in the second episode of 4 out of 6 patients.<BR>M-typable and T-typable rates of isolates were 90.7% and 97.3%, respectively. Coincidence between M and T types was 73.3%(83.0% if including strains with the same and mixed T-type). Prevalent M-serotypes were 12 and 4, but Ml, 3, or 28 was the most prevalent type of isolates in certain years.<BR>None of the 670 strains was resistant to penicillin G and cephalexin. Resistant rate of isolates to erythromycin and linecomycin was 26.5% in 1981 and 18.4% in 1982. But a marked decrease has noted since 1983 and only one has been resistant since 1986. Nineteen of the 21 erythromycin resistant strains were M-type 12 and the others were type 4 and 28. Chloramphenicol resistance was similar to erythromycin and lincomycin, and tetracycline resistance rate decreased gradually from 61.7% to less than 20% year by year.
日本感染症学会の論文

最近10年間のA群溶連菌感染症と分離菌の血清型・薬剤感受性

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日本感染症学会 | 論文

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