HBワクチン無反応および低反応例の免疫学的背景因子の検討

概要

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We investigated the immunological factors concerning the backgrouns of non-and low-responderswho could not respond well to the hepatitis B (HB) vaccine. We injected 10 μg of the recombinant HBvaccine to the medical staffs of our hospital intramuscularly three times, 199 subjects of whom couldreceive the full course of immunization with the HB surface (HBs) antigen. Wefound that 14 subjectswere non-responders whose titer of HBs antibody was under the 1.9 cut off index (C.I.) examined byradioimmunoassay (RIA) and 47 ones were low-responders whose titers were between 2.0 to 9.9 C.I. and the frequency of non-and low-responders was higher in males after the full course of HBvaccination. We chose 46 subjects and divided them into 4 groups according tothe titer of HBsantibody at 8 and 28 weeks. We compared those groups to each other according to the amounts of totalprotein, γ-globulin, Ig G, Ig A and Ig M, numbers of peripheral white blood cells and lymphocytes, andpercentages of peripheral lymphocyte and subsets of T cell including the examination by two-colorflow cytometry using monoclonal antibodies. However we could not get any significant difference inany of those immunological factors by T assay. From these findings we suggestthat the response tothe HB vaccine does not depend on the quantity of the immunological factors before vaccination but onspecific reactivity to HBs antigen after vaccination.
日本感染症学会の論文