インスリン依存性糖尿病(IDDM)患者多形核白血球Superoxide産生能の検討

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The superoxide anion (O2-) production in polymorphonuclear leukocytes stimulated by phorbol myristate acetate in IDDM and non-insulin dependent diabetes mellitus (NIDDM) was determined by the method of Johnston et al, compared with that of each age matched controls. And the correlation between O2- production and hemoglobin (Hb) Al and Alc value was investigated. The O2- production in IDDM was 24.4±7.4 (mean±SD, n mol per 4×105 cells) at 10 min. and 51.4±8.7 at 30 min., in NIDDM each 31.6±9.3, 60.2±14.4, and in controls each 40.5±4.2, 72.4±3.1. O2- production in IDDM was significantly lower than that in NIDDM (p<0.001 at 10 min. and p<0.0130min.) and controls (p<0.001 at 10 and 30 min.).O2- production at 10 and 30 min. possessed a negative correlation with Hbal and Alc value (HbAl: p<0.01 at 10 min. p<0.05 at 30 min., HbAlc: p<0.01 at 10 and 30 min.). These findings suggest that impaired O2- production might be one of the factors accounting for depressed bactericidal activity of polymorphonuclear leukocytes in IDDM, and that a protracted hyperglycemia might shed some effect on O2- production.
日本感染症学会の論文