わが国初の紅斑熱リケッチア感染症
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概要
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During the short period of summer, from the middle of May to July, 1984, there were three cases of an acute febrile disease with the characteristic exanthem successively at Aratono area in Anan city, Tokushima prefecture.The onset was abrupt, with headache and witha sudden shaking rigor and the fever was 39°Cto 40°Cor more. The rash was not tender or didn't itch, and it appeared on extremities, face and trunk, relatively in great numbers on extremities. The erythematous lesions were macular and nonfixed and then became macropapular and hemorrhagic. A tick bite was noticed in one case and in two cases out of three, eschars were observed: the erythematous induration covered by a scab in one case and the ulcerated lesion located in a center of the indurated area in the others.<BR>The generalized lymphadenopathy was not detected, and the liver and spleen were not palpable. Agglutinins against Proteus OX2 with a significant rise were found in the sera of the patients by Weil-Felix test. It was proved by indirect immunoperoxidase reaction that the sera of all cases contained no antibody against any three strain of <I>Rickettsia tsutsugamushi</I>. After the treatment with doxycycline the patients became afebrile promptly and the response was dramatic.<BR>The clinical observations and serologic examinations were led to consider these cases to be the rickettsial infection of spotted fever group, the novel disease in our country. The diagnosis was confirmed by the complement fixation test using group specific rickettsial antigens of spotted fever group.
- 日本感染症学会の論文
日本感染症学会 | 論文
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