呼吸器病原Haemophilus influenzaeの抗生物質感受性の検討--Ampicillin耐性菌の現状

概要

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<I>Haemophilus influenzae</I> strains isolated from sputum of patients with respiratory infection of adults were tested for susceptibility to 5 antibiotics. Of the 344 strains examined, 46 (13.4%) showed MICs of 6.25μg or more of ampicillin per ml. Thirty-four of the 46 strains produced β-lactamase, whilst the remaining 12 were negative. All of the β-lactamase producing strains were sensitive to cefotaxime and chloramphenicol, but 15 (44%) were resistant to tetracycline. All of the β-lactamase-non-producing ampicillin resistant strains were sensitive to tetracycline and chloramphecicol, and 9 of 12 strains were sensitive to piperacillin. One strain showed MIC of 50μg/ml of cefotaxime. Infection mixed with ampicillin resistant and sensitive strains of <I>H. influenzae</I> was found in 4 patients with chronic bronchitis.
日本感染症学会の論文