Aeromonasの腸管毒性について〔英文〕
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概要
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Two hemolytic strains of <I>Aeromonas</I> species isolated from the stool of adult patients with diarrhea were examined for enterotoxic activity by assays in mouse or rabbit ileal loop tests (mostly, mouse was used), suckling mice and Y1 adrenal tumor cell cultures. The strains produced enterotoxins antigenically different from each other and also from cholera enterotoxin and the heat-labile enterotoxin (LT) of <I>Escherichia coli</I>. The enterotoxins were cytotoxic to Y1 adrenal cells, and caused blood-stained fluid accumulation in the rabbit ileal loop test. The results suggest that two <I>Aeromonas</I> isolates produce cytotoxic agents but not cytotonic enterotoxins such as those produced by <I>Vibrio cholerae</I> and <I>E. coll</I>.<BR>The cytotoxin of <I>A. hydrophila</I> strain AK-1 and of A.<I>sobria</I> strain AK-2 was inactivated by heating at 56°C for 10 min. Maximal production of AK-1 toxin occurred in the early stage of growth at temperatures between 30°C and 41°C.
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