Acinetobacter calcoaceticusに関する研究--マウスに対する菌力および各種抗生物質の治療効果

概要

論文の詳細を見る
The virulence of 40 clinical isolates of Acinetobacter calcoaceticus was studied by means of an experimental infection model in mice. The therapeutic efficacy of antibiotic treatment and the responses to nonspecific defense mechanisms were concurrently investigated. The LD50 value (cells/mouse) of A. calcoaceticus inoculated i. p. with mucin was>106 cells/mouse for. about 60% of the strains and ≤106 cells/mouse for the remaining 40%, with 15% of the latter strains being highly virulent (LD50: 103-105 cells/mouse). LD50 values derived by i. p. or i. v. inoculation without mucin were considerably lower than when mucin was concomitantly used. Tests on the therapeutic efficacy of antibiotics in the treatment of experimental i.p. infections revealed that tetracyclines, aminoglycosides and peptides, compounds which were highly active in vitro, were likewise very effective in vivo. The response to nonspecific defense mechanisms was investigated by testing the influence of serum and phagocytosis by polymorphonuclear neutrophils. Virulent strains were resistant to both effects.
日本感染症学会の論文