岡山県における百日咳の発生について
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概要
- 論文の詳細を見る
Namely, an infant died by some unknown cause after D. P. T. (Diphtheria-Pertussis-Tetanus) vaccination. Since then, D. P. T. vaccination has been stopped in Okayama Prefecture. In June, 1975, there was frequent incidence of pertussis syndorome in children predominantly in southern regins of Okayama Prefecture, in the age range of 1 to 3 years old. These patients were clarified to have had immunization or incomplete immunization on inquiry. Pertussis has rarely occurred and sporadically during the past decade in Okayama Prefecture. Therefore, we engaged ourselves in the isolation of Bordetella Pertussis from patient nasophanyngeal swab specimens and titration of antibody in the sera to Bordetella Pertussis was done by agglutination test from such patients. As a result, Bordetella Pertussis was isolated from 35 patients out of 194 patients. Its bacterial antigenic structure was to be the same to 1, 3, (4), 6 as the agents currently causing the incidence of this disease in Japan. Titration of 134 pairs of the sera from these patients confirmed to raise the antibody titer of Bordetella Pertussis. In order to ascertain whether or not this disease is caused by adenovirus, these sera were simultaneously examined with CF antibody by micromethods. Adenovirus antibody has shown no significant difference in the values as compared with examinations of 115 sera from infant patients of non-pertussis syndrome. According to many investigators, however, pertussis syndorome is elicited by adenovirus. In contrast, the recent outbreake of pertussis in Okayama Prefecture had no relation, whatever to this but caused only by Bordetella Pertussis.
- 日本感染症学会の論文
日本感染症学会 | 論文
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