外科領域におけるTalampicillin hydrochlorideの基礎的,臨床的検討 (タランピシリン論文集)

概要

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The fundamental and clinical studies on Talampicillin hydrochloride (TAPC) in the surgical field were performed, and the following results were obtained. Blood levels and urinary excretions were measured in 3 healthy adults administered single oral dose of 250 mg of TAPC early in the morning at fasting. The maximum blood level on the average was achieved 1 hour after administration, and average concentrations were shown 3.8μg/ml at 30 minutes, 4.5μg/ ml at 1 hour and 1.4μg/ml at 2 hours following the initiation. Urinary recovery rate within 6 hours was 55.1% of an administered dosage on the average. Eleven cases suffering from acute suppurative infections of soft tissue in surgical field were treated with TAPC. Excellent improvements were obtained in 3 cases, good in 4 and moderate in 3. No change was observed only in one case. The effective rate including excellent, good and moderate cases resulted in 90.9%. The side effect was noted in one case as extensive skin rash. No other side effect such as gastrointestinal disturbance was observed in this investigation.
日本感染症学会の論文