外科におけるTalampicillin抗菌力,吸収,排泄,臓器内分布,代謝および臨床応用について (タランピシリン論文集)
スポンサーリンク
概要
- 論文の詳細を見る
Fundamental and clinical studies on Talampicillin were performed and the following results were obtained.<BR>1) Antibacterial spectrum: Antibacterial spectrum of Talampicillin was the same as that of Ampicillin.<BR>2) Susceptibility of clinical isolates: Talampicillin showed similar antibacterial activity to Ampicillin against <I>Staphylococcus aureus</I> and <I>E. coli</I>, but both antibiotics were inactive against <I>Klebsiella pneumoniae</I> and <I>Pseudomonas aeruginosa</I>.<BR>3) Concentrations in the blood and urine: Concentrations in the blood and urine of three healthy volunteers taking Talampicillin 500 mg were determined by the cylinder plate method using PBS as standard.<BR>The peak concentration in the blood was observed 1-hr after administration at an average level of 9.6μg/ml. The urinary concentration reached a peak after 2-hrs. at an average of 1183.3μg/ ml. The urinary recovery rate in the 6-hrs. period was 71.9%.<BR>4) Tissue concentration: Tissue concentrations in groups of rats each consisting of three SD rats were found highest in the liver, followed by the kidney, serum, heart, lung and spleen, in that order. But only a trace of the drug was observed in muscle.<BR>5) In vivo metabolism: Metabolism of Talampicillin was studied on urine of human receiving Talampicillin by bioautogram prepared with TLC. It was found that Talampicillin was metabolized into Ampicillin and then excreted in the urine.<BR>6) Talampicillin was given to 16 patients with surgical infectious diseases and the following results were obtained good in 10, poor in 5, unknown in 1. The effective rate was 66.7%.<BR>Vertigo and itching were noted in one of these cases. But no other side effect was observed.
- 日本感染症学会の論文
日本感染症学会 | 論文
- 看護学生における風疹, 麻疹, 水痘, ムンプス感染防止対策 : 抗体価測定とワクチン接種
- 本邦において初めて流行が確認された小児の human metapneumovirus 感染症の臨床的, 疫学的解析
- つつが虫病および日本紅斑熱について発生頻度が異なる地域での市民医学講座参加者における認知度比較
- 日本の検疫所における遠隔疫学調査による多剤耐性赤痢菌株のインド国内における定着の証明
- HIV-1感染者血清中の逆転写酵素活性阻止抗体の動態