Adaptive feedback logic for neutrophil classification.
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概要
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This paper describes a classification logic to classify a neutrophil either as the band neutrophil or the segmented neutrophil. In a typical case, a band neutrophil has a horseshoe-shaped nucleus while a segmented neutrophil has separated nuclei. So it is very easy to distinguish one from the other. But in the case where nuclei are overlapped or touching, it is difficult to distinguish one from the other.On the other hand, the ratio of the number of band neutrophils to that of the segmented ones is low in normal samples. In the case that the above mentioned ratio is extremely high, the correlation between the counting of the technologist and that of the system might become worse if the fixed classification logic is applied.We developed an adaptive feedback logic for the neutrophil classification, which has three logics. The first is the logic to classify the typical band-form or the typical segmented-form. The second is the logic to presume the ratio of the number of band neutrophils to that of segmented ones in the slide from the number of the typical band class, that of typical segmented class and the total number of neutrophil class, all of which are obtained by automated classification logic. The third is the logic to classify the nontypical form neutrophil into two classes in the discriminant space where discriminant threshold is selected by the ratio presumed in the second logic. This adaptive feedback logic improved the correlation between the counting of the technologist and that of the system in various kinds of samples.
- 一般社団法人 日本生体医工学会の論文
一般社団法人 日本生体医工学会 | 論文
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