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A new hardware simulator system has been developed in order to contribute to the study of the controlling mechanisms of the neuro-muscular system on the peristaltic movement in the gastro-intestines.This model (simulator) is composed of the following three subsystems: (1) An electronic circuit membrane model which showed similar V-I-t (voltage-current-time) characteristics of the smooth muscle in both the voltage clamp and the current clamp experiments. The smooth muscle membrane model had active cable characteristics with the conduction velocity of about 3.5cm/s. (2) Simplified neural networks of the Meissner's and Auerbach's plexus, which were composed of the voltage-controlled oscillators and had analog signal processing and pulse transmission capabilities. (3) Transportation models which simulated the transportation of the inner food by the controlled muscle tension/contraction, and simulated the detection of the feedback quantities, i. e., the tension difference between the neighboring units depending upon the mass of the objective food.Macroscopic peristaltic movements were fundamentally well simulated by the proposed model in spatio-temporal patterns of the movement (especially the controlling function of the Auerbach's plexus), transportation velocity of the food (1.2-1.9cm/min), etc. Since overall system was developed to work in real-time, the simulator could be directly combined with the physiological experiments for the quantitative evaluation, e. g., the measured multichannel nerve impulse trains could be put to the simulator.
- 一般社団法人 日本生体医工学会の論文
一般社団法人 日本生体医工学会 | 論文
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