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This paper describes a new multi-microelectrodes system which has been developed to measure simultaneously the activities of adjacent neurons constituting local neural networks of the brain. This multi-microelectrodes system aims at 'the following features : (1) minimization of the brain tissue area occupied by total microelctrodes and possibility of simultaneous recording of single-unit potentials of closely spaced neurons in such a local fine area; (2) clarification of the recording locations of microelectrodes in measuring the activities of neurons; (3) possibility of independent and parallel driving of each microelectrode into the brain. <BR>To accomplish all these features, it is necessary to find a solution to satisfy the following antinomy requirements : that is, shaping an electrode wire into much finer structure and also improving the structural strength of an electrode wire. To solve these problems, the architecture of our new type of multi-microelectrodes is as follows : (1) reinforcement of the structural strength of a microelectrode by means of coupling the set of microelectrodes tightly to each other; (2) magnetical coupling of adjacent microelectrodes so that each of them can be driven independently.<BR>Especially, as a microelectrode material, a platinum-cobalt alloy wire is used from the fine structural workability and excellent magnetical characteristic points of view. In addition to the description of the structural features of multi-microelectrodes, this paper also deals with several newly developed techniques concerned with the microelectrode fabrication : (1) thermal processing of Pt-Co alloy to achieve excellent magnetical characteristics; (2) electrolytic polishing method to taper a Pt-Co alloy wire tip; (3) coating method of the thin and strong electrical insulation layer on a microelectrode; (4) excoriation processing of the fine insulation layer on the tip by heating the microelectrode tip; (5) multi-dimensional micromanipulator for the independent penetration of each microelectrode.
- 一般社団法人 日本生体医工学会の論文
一般社団法人 日本生体医工学会 | 論文
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