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A simulation study is made to analyse the coronary arterial blood flow pattern in terms of the intramural hemodynamic parameters. In the present study, the variable resistances of the intramural portion of coronary vessels are estimated from the extravascular pressure and the intravascular pressure, based on the elastic diagram of each blood vessel. The phasic coronary flow andthe hemodynamic parameters were obtained by the analog digital simulator from the time-serial values of the aortic pressure, left ventricular pressure, right atrial pressure, and left ventricular volume. The obtained flow pattern in the extramural coronary artery was in excellent similarity with that measured with an electromagnetic flow meter. The coronary venous flow showed twoforward flows, the larger one appearing in the systolic phase and the smaller one in the diastolic phase. The extramural coronary arterial flow in systolic phase was strongly suggested to be primarily by the "throttling mechanism", and partially also by the "massage mechanism" of the intramural extravascular pressure. The good agreement of these results with the experimentally demonstrated findings indicates that the coronary circulation model in this study is reasonable andcompatible with further simulation to evaluate the other factors.
一般社団法人日本生体医工学会の論文