Evaluation of Activated Eosinophil Infiltration after Treatment for Allergic Rhinitis Using Trichloroacetic Acid

概要

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We studied 24 patients with perennial allergic rhinitis combined with deflected nasal septum who showed no improvement after treatment with 80w/v % trichloroacetic acid (TCA) on the non-deflected nasal septum side regardless of time course. We determined if TCA was able to suppress reagin dependent allergy by analysis in a two-way classification using the data counting the number of activated eosinophils that existed in the inferior turbinate mucosa of the TCA applied (non-deflected) and non-applied sides. The results showed that the interaction between TCA treatment and eosinophil activation in the applied and non-applied sides was significant (p<.01) and that the ammount of sosinophil activation decreased according to the effects of the treatment.We concluded that if the onset of allergy occursequally and at the same time to both the applied and non-applied sides, we can speculate that eosinophil infiltration to the applied side is decreased due to regional suppression of cytokines effectiveness and that TCA treatment suppress reagin dependent allergy.
特定非営利活動法人日本頭頸部外科学会の論文