Examination of efficacy of levofloxacin for prevention of postoperative infection
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概要
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Background: In the field of head & neck surgery in otolaryngology, antimicrobial agents are administered in order to prevent infections during the perioperative period caused by mainly Gram-positive coccus such as Staphylococcus aureus. Short-period administration of penicillin or first generation cephems antibiotics is recommended for clean/clean-contaminated operations. For a short operation, a single administration within 30 minutes from the start of operation is considered sufficient. However, in Japan it is customarily administered for several days after the operation in many cases. Purpose: Oral antimicrobial agent Levofloxacin (LVFX, Cravit(R)) was administered in order to prevent postoperative infection in patients who underwent clean/clean-contaminated operations in the field of head & neck surgery in otolaryngology, and its efficacy was examined. Patients and method: Of the patients who underwent clean/clean-contaminated operations in the operating room of the Department of Otolaryngology, Hokkaido University Hospital from July 2007 to February 2008, patients who underwent minor or intermediate operations for mouth, pharyngolarynx, trachea, or neck were selected. Patients who had experience of irradiation, or past history of surgical site operation/infection, or those who were considered to have a high risk of infection due to systemic complications and to whom the doctor in charge judged it appropriate to intravenously infuse antimicrobial agents, were excluded. Results: Agents were administered to 71 patients, and postoperative infection did not occur in any of them. Conclusion: In clean/clean-contaminated operation in the field of head & neck surgery in otolaryngology, intravenous antimicrobial injection is commonly used to prevent postoperative infection, but these results suggest that a sufficient effect can be achieved by a single administration of the oral antimicrobial agent LVFX.
- 特定非営利活動法人 日本頭頸部外科学会の論文
特定非営利活動法人 日本頭頸部外科学会 | 論文
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