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A retrospective study was performed on 31 patients with oral, oropharyngeal and hypopharyngeal squamous cell carcinoma treated by salvage surgery after primary chemoradiotherapy (CRT). Five-year overall survival rates for these patients were 35%. The survival rates for lymph node negative cases diagnosed on the primary CRT were significantly better than those for lymph node positive cases. The survival rates for stage I and II by the restaging on the salvage surgery were significantly better than those for stage III and IV cases. Postoperative complications were found in 45% of the patients. The cases treated by tumor resection with reconstruction surgery showed higher rates of postoperative complications than the cases treated by tumor resection or neck dissection without reconstruction surgery. Furthermore, the outcomes for the cases with postoperative complications were significantly worse than for the cases without postoperative complications. These results suggest that the diagnosis of recurrence at an early stage is important for improving the outcomes of salvage surgery. In addition, in order to reduce the recurrence and salvage surgery, the indication and methods of the primary CRT should be carefully examined.
特定非営利活動法人日本頭頸部外科学会の論文