Malignant Fibrous Histiocytoma of the Larynx : A Case Report

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We report a rare case of malignant fibrous histiocytoma of the larynx. A 70-year-old Japanese woman presented with an increasing hoarseness. A 10-mm tumor of the vocal cord was discovered on nasopharyngoscopy; however cord function was normal. CT and MRI findings confirmed a tumor of the larynx. Laryngomicrosurgery was performed under general anesthesia resulting in complete removal of the tumor. Histopathological examination revealed the mass to be composed of f ibroblast-like and histiocyte-like cells, exhibiting a connective tissue structure, consistent with the pathological appearance of MFH. No recurrence or metastasis has been reported during 18 months of postoperative follow-up and the patient continues to be monitored in our clinic. The literature contains only a small number of treated cases of laryngeal MFH, hence no standard protocol of treatment currently exists, and the disease appears to be treated on a case-by-case basis. In Japan, the tumor tends to be removed at an earlier stage than in other countries and laryngomicrosurgical resection is consequently the most common therapeutic choice; however reports of recurrence and metastasis are few. Tumor size thus appears to be related to prognosis.
特定非営利活動法人日本頭頸部外科学会の論文