Effect of 1α, 24(R)(OH)2D3 on calcium and phosphorus metabolism in X-linked hypophosphatemic mouse

概要

論文の詳細を見る
The X-linked dominant mutation in the laboratory mouse (gene symbol Hyp) is regarded as a model of familial hypophosphatemic vitamin D resistant rickets in man.We investigated the effect of 1α, 24(R)(OH)2D3, recently synthesized from fucosterol, on plasma calcium and phosphorus metabolism in Hyp mice.Single administration of 1α, 24(R)(OH)2D3 50ng (P. O.) significantly increased plasma calcium level only in the +/Y mice but not significantly in the Hyp/Y mice.Successive 4 weeks administration of 1α, 24(R)(OH)2D3 significantly increased plasma calcium level in the +/Y mice but the elevation of this level in the Hyp/Y mice was not so high as that in the +/Y mice. Meanwhile, plasma phosphorus level was improved to the normal range in Hyp/Y mice with increased % TRP after administration for 4 weeks. In addition, histological study revealed reduction of osteoid tissue in Hyp/Y mice after administration of 1α, 24(R)(OH)2D3.It is therefore expected that 1α, 24(R)(OH)2D3 will be effective for the treatment of familial hypophosphatemic vitamin D resistant rickets.
日本骨代謝学会の論文