Effect of Sex Steroid-Thyroid Hormone Mixture on an Experimental Model of Osteoporosis

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The effect of Sex steroid-thyroid hormone mixture (pregnenolone 1.0mg, androstenedione 1.0mg, androstendiol 0.5mg, testosterone 0.1mg, estrone 5μg, thyroid gland 7.5mg) on the bone mass were studied in the osteoporotic model rats.A hundred-twenty rats were fed on low a calcium (0.1%)-low protein (5%) diet and divided into 5 groups. Group A was sham-operated and Group B was oophorectomized. Group C, D and E were experimental groups administrated 0.6, 3 and 6mg/kg/day MTH after ovariectomy respectively. In the experimental group, histological bone area of the tibia were increased 3 weeks later and percent resorption surface were significantly decreased. No difference were noted in the percent osteoid surface. Ca content of the lumbar spine were significantly increased 6 weeks later and the breaking force were also increased on 9 weeks.These results suggest that sex steroid-thyroid hormone mixture may improve bone change in postmenopausal osteoporosis by preventing bone resorption.
日本骨代謝学会の論文