細菌の薬物に対する抵抗性獲得現象について:III. 薬物抵抗性変異菌の選択的発育について

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(1) When ordinary strains of S. aureus or E, coli were cultured in the presence of penicillin or streptomycin, the growth curve showed a characteristic upswing at later stages of culture. This phenomenon was shown to be due to the development of resistant cells which either had existed sparsely in the original inocula or had spontaneously appeared as a mutant during the growth of less resistant cells. In contrast to the bacteria mentioned above, L. casei produces a population which is quite homogeneous in respect to the resistance of individual cells towards penicillin and streptomycin. In the culture of this bacterium, there occurred no upswing of growth curve in the presence of said antibiotics.(2) The rise of growth curve owing to the development of resistant cells was also observed when ordinary strain of S. aureus was cultured in the presence of furacin, a strain was obtained which may be regarded as practically "pure" or homogeneous in respect to the resistance towards the drug. With this strain no ascension of the growth curve occurred at later stages of culture in the presence of furacin.(3) The possibility of the occurrence of selective growth of spontaneous mutants under the influence of various antibacterial substances was discussed.
公益社団法人日本植物学会の論文