Studies on Animal Models as Approach toward Future Medicine:—Contribution to Predictive and Preventive Medicine of Stroke

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In addition to artificially-induced experimental models for stroke such as thrombo-embolism and ligation of cerebral arteries, a unique model, the stroke-prone spontaneously hypertensive rat (SHRSP) developing hemorrhagic or thrombotic stroke spontaneously without exception nowadays, was established in Japan and has been extensively studied world-wide for the pathogenesis and prevention of stroke. Moreover, in search of"a model for lacular stroke"which is preponderant cause of cerebrovascular dementia in aged populations such as Japan, we recently succeeded in establishing the model by cross breeding between SHRSP and OM strain with accelerated platelet aggregavility.<BR>Studies on the pathogenesis showed that genetic factors (consisting of more than 5 major genes) and their interaction with environmental, especially nutritional factors such as salt, protein and lipid intakes were important ; Cultured smooth muscle cells obtained from SHRSP are more vulnerable to hypoxia than those from normotensive control rats, offering the evidence suggestive of cellular desposition to cerebrovascular damages. Severe hypertension, through cerebral blood flow reduction in the brain region fed by recurrent arteries, induces initially medial necrosis of small intracerebral arteries which is the basic vascular lesions for either cerebral hemorrhage or infarction. Dietary conditions with high Na/K ratio accelerate the development of such arterionecrothrombogenic strokes. Not only K but also dietary fibers, especially seaweed or alginic acid obtained from it, counteract the adverse effect of salt and the preventive mechanism of stroke by dietary fibers has been proven to be due to the reduction of gastro-intestinal Na absorption. In contrast, protein-rich diets decrease the incidence of stroke through the attenuation of hypertension, the acceleration of urinary Na excretion and the preservation of vascular wall distensibility. Further, taurine rich in fish protein has been proven to prevent stroke by the neurogenic attenuation of severe hypertension. Among several fatty acids chronically given to SHRSP palmitoleic acids (POA) are proven to be effective for stroke-prevention even in SHRSP on high salt diets.<BR>Some indices such as early development of hypertension, tendency toward cardiovascular hypertrophy and biomembrane abnormalities resulting in intracellular Na retention, are possibly related to predisposition to hypertension and stroke and may be utilized for the scientific prediction of stroke. Thus, stroke is experimentally predictable, and evidently preventable by the control of blood pressure, nutritional conditions and also of thrombogenesis.<BR>The most important message obtained from our experimental models of stroke is"stroke can be prevented by non-pharmacological dietary intervention even in animal models strongly predisposed to cerebrovascular diseases."Accumulating evidence obtained by our epidemiological and clinical studies support that these experimental findings in animal models can be applied to humans.
公益社団法人日本実験動物学会の論文

Studies on Animal Models as Approach toward Future Medicine:—Contribution to Predictive and Preventive Medicine of Stroke

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概要

公益社団法人日本実験動物学会 | 論文

スポンサーリンク

Studies on Animal Models as Approach toward Future Medicine:—Contribution to Predictive and Preventive Medicine of Stroke

スポンサーリンク

概要

公益社団法人 日本実験動物学会 | 論文

スポンサーリンク

公益社団法人日本実験動物学会 | 論文