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The basic helix-loop-helix leucine zipper transcription factor MITF is important for the development of mast cells. The mutant <I>tg</I>/<I>tg</I> mice, which do not express MITF, lack mast cells in tissues. For the development of mast cells, not only mast cell precursors but also environmental factors are necessary. The mutant <I>W</I>/<I>W<SUP>v</SUP></I> mice that also lack mast cells like <I>tg</I>/<I>tg</I> mice possess normal environment but abnormal mast cell precursors. Since MITF is expressed in both mast cells and tissues where mast cells develop, the <I>tg</I>/<I>tg</I> mice may show abnormalities in both mast cell precursor and tissue environment. We investigated the abnormalities of mast cell precursors and environment in <I>tg</I>/<I>tg</I> mice by skin and bone marrow transplantations. When bone marrow cells of <I>tg</I>/<I>tg</I> mice were transplanted to <I>W</I>/<I>W<SUP>v</SUP></I> mice, mast cells did not develop in tissues. The number of developing mast cells in the skin from <I>W/W<SUP>v</SUP></I> mice was much lower when grafted to <I>tg/tg</I> mice than when grafted to normal (+ / +) mice. These indicated that mast cell precursors of <I>tg/tg</I> mice did not develop in tissues. When bone marrow cells of + / + mice were transplanted, the number of developing mast cells was significantly lower in <I>tg</I>/<I>tg</I> mice than in <I>W</I>/<I>W<SUP>v</SUP></I> mice. When the skin was grafted to + / + mice, the magnitude of increase of mast cell number was lower in the graft from <I>tg<I>/</I>tg</I> mice than in the graft from <I>W<I>/</I>W<SUP>v</SUP></I> mice. These showed that the tissue environment for mast cell development was defective in <I>tg</I>/<I>tg</I> mice. MITF was essential for both mast cell precursors and tissue environment.
- 公益社団法人 日本実験動物学会の論文
公益社団法人 日本実験動物学会 | 論文
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