T Cell Depression, Autoantibody Production and Development of Vascular Disease in Spontaneously Hypertensive Rats (SHR)
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A strain of spontaneously hypertensive rats (SHR) has been established as an animal model for human essential hypertension by Okamoto and Aoki. Recently, we found that these SHR have various immunological abnormalities. The percentages of rosette-forming cells and of Thyl.1-positive cells in the thymus of the SHR were lower than those of age-matched W rats. T cell functions such as antibody responses to sheep red blood cells and blastogenic responses to PHA and Con A of SHR spleen cells were significantly suppressed in comparison with those of W rats and progressively decreased with increasing age. The T cell depression of SHR was closely associated with a deficiency in the production of thymic factors relating to T cell differentiation. Furthermore, SHR were found to produce a natural cytotoxic autoantibody (NTA) against thymocytes after they were 1 month old and throughout their lives thereafter. The SHR which showed high blood pressure were always also accompanied with high NTA titers and a high incidence of arterial lesions. Transplantation of neonatal W thymus tissues into 1-week-old SHR showed a long-lasting recovery of T cell numbers and functions. The development of NTA and arterial lesions was also prevented by the neonatal W thymus grafts. When histological examinations were performed on 8-month-old SHR grafted with neonatal W thymus, none of the SHR showed arterial lesions by either macroscopic or microscopic examinations. The blood pressure of the grafted SHR remained at lower levels and was not elevated by aging. These results suggest that there is a close correlation between immunologic abnormalities and the development of hypertension in SHR.
- 公益社団法人 日本実験動物学会の論文
公益社団法人 日本実験動物学会 | 論文
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