Drug Research Using Spontaneously Hypertensive Rats (SHR)

スポンサーリンク

概要

• 論文の詳細を見る

• Spontaneously hypertensive rats (SHR) have been regarded as a useful animal model for human essential hypertension. In 1974, stroke-prone SHR (SHRSP) rats were successfully separated from the substrains of SHR. At the prehypertensive phase, the ability of SHR and SHRSP to excrete sodium and water was reduced. Moreover, a reduction of renal perfusion pressure at the hypertensive phase resulted in a marked decrease in sodium and water excretion in both strains of SHR. These results support the hypothesis that kidneys of SHRs require a higher arterial pressure than kidneys of normal rats to excrete a given amount of sodium and water. In addition, reduction in renal perfusion pressure, which seems to be due to the hypertensive arteriolar changes in renal cortex, is likely to be related to the pathogenesis of stroke in SHRSP. From these findings, we speculated that the drugs improving renal hemodynamics in SHR and SHRSP may be useful for the treatment of hypertension and useful for prevention of stroke. In view of our speculation, we successfully developed a new calcium antagonist with a potent inhibitory action against the onset of stroke in SHRSP.<BR>SHRSP rats are also useful for evaluation of the therapeutic drugs for neurological signs in patients with stroke. In the present report, idebenone is introduced as an example of a drug for treating the neurological deficits. The drug showed beneficial effects on post-stroke symptoms, such as emotional changes and decreased spontaneous activity, observed in SHRSP.<BR>The results indicate usefulness of SHR and SHRSP for the development of new cardiovascular drugs.

• 公益社団法人 日本実験動物学会の論文

公益社団法人 日本実験動物学会 | 論文

• Effects of W and Sl Gene on Germ Cell Differentiation.
• Establishment of a Highly Reproducible Model of Human/Murine SCID Mouse Arthritis.
• タイトル無し
• タイトル無し
• タイトル無し

もっと見る

スポンサーリンク