Maintenance of SHR Substrains and Development of a New Rat Strain

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Comparative studies were performed on four SHR substrains; SHR C, SHR B2, SHRSP and M-SHRSP. When the blood pressure increased to 210 mmHg and above in SHRSP and MSHRSP, the plasma renin concentration, cerebrospinal fluid pressure and brain water content began to increase alongside of these elevations in blood pressure and showed significantly positive correlations. High molecular weight renin was also recognized after the blood pressure elevation above 210 mmHg. Blood pressures for SHR C and SHR B2 were below 210 mmHg.<BR>Continued successive selective brother-sister breeding of SHC and M-SHRSP hybrids produced a colony with severe hypertension (blood pressure above 210 mmHg) and marked hyper-cholesterolemia (plasma cholesterol level above 400 mg/dl) .
公益社団法人日本実験動物学会の論文