Cerebral Dysfunction of Rolling Mouse Nagoya—A Study with Local Cerebral Glucose Utilization

スポンサーリンク

概要

• 論文の詳細を見る

• Rolling mouse Nagoya (rolling) is a neurological mutant mouse that shows an incoordination of the hind limbs and gait disturbance. Morphological studies of the brain have not revealed any definite abnormalities in rolling. Mainly due to resemblance of the gait disturbance to cerebellar ataxia, rolling has been regarded as an animal model of hereditary cerebellar ataxia.<BR>In order to elucidate the neural mechanism of the motor disturbance of rolling, local cerebral glucose utilization (LCGU) was studied in rolling (genotype <I>rol/rol</I>), its heterozygote (+/<I>rol</I>) and normal mice (+/+), as well as in weaver mouse (weaver) that has a definite degeneration of the granule cells of cerebellar cortex. Pharmacological effects of dopamine agonist, apomorphine, and antagonist, haloperidol, were also studied. LCGU has been proved to be an excellent parameter for observing local brain activity.<BR>Rolling showed a markedly increased LCGU in the globus pallidus, entopeduncular nucleus, subthalamic nucleus and substantia nigra pars reticulata, bilaterally, compared to +/<I>rol</I> and +/+. A part of the cerebellar cortex showed a tendency to reduction of LCGU when compared with +/+, but not with +/<I>rol</I>. Weaver showed a decreased LCGU in the granular layer of the cerebellar cortex, a consistent finding with the morphological studies. The basal ganglia of weaver, however, did not show any abnormalities. These results suggested that rolling has a primary dysfunction in the basal ganglia, not secondary to disturbance of the cerebellum. Clinical observation also supported that the motor disturbance of rolling is probably due to extrapyramidal dysfunction.<BR>LCGU studies with apomorphine and haloperidol in rolling and its control mice suggested that the effect of apomorphine on LCGU was reduced or abolished in the basal ganglia of rolling, and this alteration was brought about by a dysfunction of the striatum, consequently affecting the functions of the globus pallidus, entopeduncular nucleus, subthalamic nucleus and substantia nigra pars reticulata.<BR>These observations indicated a possibility that rolling is an animal model of hereditary extrapyramidal diseases.

• 公益社団法人 日本実験動物学会の論文

公益社団法人 日本実験動物学会 | 論文

• Effects of W and Sl Gene on Germ Cell Differentiation.
• Establishment of a Highly Reproducible Model of Human/Murine SCID Mouse Arthritis.
• タイトル無し
• タイトル無し
• タイトル無し

もっと見る

スポンサーリンク