Incidental mesangial IgA deposition in minimal change nephrotic syndrome (MCNS).

概要

論文の詳細を見る
The frequency of incidental mesangial IgA deposition and its clinicopathological features were investigated in patients with minimal change nephrotic syndrome (MCNS) . Mesangial IgA deposition was present in 15/63 patients (23.8 %), and co-deposition of IgA and C3 was present in 10/63 patients (15.9 %). The serum IgA concentration was significantly higher in IgA (+) patients than in IgA (-) patients (341±79 mg/dl vs. 252±99 mg/dl, p=0.034) . The urinary red blood cell count tended to be higher in IgA (+) patients than in IgA (-) patients (12.8±24.9 vs. 5.0±7.9 counts/HPF, p=0.58) . Histologically, no significant differences were observed between IgA (+) and IgA (-) patients. After steroid treatment, 14 patients with mesangial IgA deposition showed complete remission and one patient had persistent proteinuria . The microhematuria also disappeared after steroid treatment in 13/15 patients (86 .7 %), although it reappeared in 6/13 patients (46 %) during reduction of steroid administration. The present study indicated that the incidental mesangial IgA deposition was frequently observed in MCNS patients (23 .8 %) . The phenomenon of mesangial IgA deposition was related to the higher concentration of serum IgA . However, no influence of mesangial IgA doposition in MCNS patients was found on the post treatment amount of proteinuria, renal function and clinical outcome of MCNS.
社団法人日本腎臓学会の論文