Responses of Renin-Angiotensin-Aldosterone System to Insulin Hypoglycemia in Patients with Essential Hypertension
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Responses of renin, aldosterone, cortisol and dopamine β-hydroxylase (DBH) to insulin hypoglycemia were investigated in 9 normal subjects and 11 patients with essential hypertension. Patients with normal renin essential hypertension (NREH) showed a significant rise in plasma renin activity (PRA) in response to insulin hypoglycemia as well as in normal subjects, while in patients with low renin essential hypertension (LREH) no significant rise in PRA but a elevation of plasma aldosterone and cortisol were observed. The basal levels of serum DBH activity and ΔDBH values after the administration of insulin were lower in the LREH group than in the NREH group. These results suggest that the autonomic nervous system may be so hypotonic in the LREH that cause a hyporesponse of PRA to insulin hypoglycemia, and that the pituitary adrenal axis may be involved in the release of aldosterone under this condition instead of the renin-angio-tensin system.
- 社団法人 日本腎臓学会の論文
社団法人 日本腎臓学会 | 論文
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