Participation of renal tubular epithelial antigen and HLA-DR antigen in pathogenesis of membranous nephropathy.
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概要
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In order to clarify the relationship between the tubulo-interstitial lesions and the sub-epithelial deposits along the glomerular capillary wall in membranous nephropathy (MN), participation of renal tubular epithelial antigen (RTE) and HLA-DR related antigen (Ial) in pathogenesis of the disease was studied. Twenty-nine biopsied and one autopsied kidney specimens obtained from 30 patients with MN (14 males and 16 females) were examined with the indirect immunofluorescence technique using monospecific rabbit anti-serum against human RTE and monoclonal anti-human Ial murine antibody. Fine granular deposits of RTE along the glomerular capillary wall was noted in five patients (17%), two with gouty kidney, one with malignant rheumatoid arthritis and two with idiopathic MN. These positive patients had moderate to severe tubulo-interstitial lesions, In 17 patiens (57%), lal antigen was diffusely expressed in tubular epithelial cells and the grade showed a positive correlation with the grade of tubulo-interstitial lesions (rs=0.579, p<0.001) . In addition, granular expression of Ial antigen in tubular epithelial cells was also observed in all RTE positive, but not in negative patients. Based on these results, it has been suggested that RTE may be involved in the pathogenesis in some patients with MN accompanied with tubulo-interstitial lesions and consequent aberrant Ial expression in tubular epithelial cells may play an important role in recognition of RTE as non self.
- 社団法人 日本腎臓学会の論文
社団法人 日本腎臓学会 | 論文
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