Effects of a low protein diet and essential amino acid supplementation therapy on the progression of chronic renal failure.
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The effects of a low protein diet and essential amino acid supplementation therapy on the rate of progression of chronic renal failure caused by chronic glomerulonephritis were examined retrospectively in 31 patients. A comparison of the rates of progression of renal failure in the low protein diet group with those in the non-low protein diet group was made using the slopes of regression lines between the reciprocal values of the serum creatinine and time. The mean slope of-5.4×10<SUP>-3</SUP> dl/mg/ month in the low protein diet group was significantly different from that of -9.9×10<SUP>-3</SUP> dl/mg/month in the non-low protein diet group. In addition, the influence of the low protein diet therapy on the progression of chronic renal failure was examined in 4 patients who started on the low protein diet therapy in mid-course of the follow-up period. Three of them revealed significantly smaller values of serum creatinine during the low protein diet therapy than those predicted by extrapolation of their respective rates of progression before treatment. The effect of essential amino acid supplementation therapy on the rate of progression of chronic renal failure was studied in 2 patients who changed from a low protein diet to essential amino acid supplementation therapy. The creatinine concentrations under the essential amino acid supplementation therapy increased at a significantly slower rate than predicted during the low protein diet alone. These results suggest that the low protein diet therapy may have slowed the progression of chronic renal failure, and that the essential amino acid supplementation therapy could be more effective for retardation of the progress of chronic renal failure than the low protein diet alone.
- 社団法人 日本腎臓学会の論文
社団法人 日本腎臓学会 | 論文
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