Erythrocyte sodium ion transport systems in DOCA-salt, goldblatt and spontaneously hypertensive rats.
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An altered erythrocyte sodium ion transport of essential hypertensive subjects has been observed in relation to the pathogensis of hypertension. In this study, erythrocyte sodium ion transport systems as well as sodium and potassium content were examined and the following results were obtained in DOCA- salt (DSH), two-kidney, one clip Goldblatt (2KH) and spontaneously hypertensive rats (SHR). 1. Erythrocyte sodium content was significantly higher in SHR than in controls (p <0.01).In DSH and 2KH, erythrocyte sodium content was similar with controls. 2. Erythrocyte potassium content was significantly lower in DSH than in controls (p <0.01).In 2KH and SHR, erythrocyte potassium content was similar with controls. 3. The Na<SUP>+</SUP>-K<SUP>+</SUP> pump activity was significantly higher in SHR than in controls (p <0.01). Significant differences in Nay-K pump activity, however, could not be demonstrated in DSH and 2KH compared to controls. 4. The Na<SUP>+</SUP>-K<SUP>+</SUP> cotransport was similar with controls in all hypertensive rats. 5. The passive Na<SUP>+</SUP> permeability was significantly higher in SHR than in controls (p <0.01). In DSH and 2KH, the passive Na<SUP>+</SUP>permeability was similar with controls. 6. An increase in erythrocyte Na<SUP>+</SUP>- K<SUP>+</SUP>pump activity in SHR might reflect compensatory mechanism for the increased inward leak of sodium and the increased content of erythroctye sodium might be related to the pathogenesis of hypertension. 7. In DSH and 2KH, none of the erythrocyte abnormalities observed in the SHR were present, suggesting that latter alteration are probably genetically determined and not a consequence of elevated arterial pressure.
- 社団法人 日本腎臓学会の論文
社団法人 日本腎臓学会 | 論文
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