The effect of antigenic charge on the glomerular deposition of immune complexes in acute serum sickness of rabbits.
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概要
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We examined the role of antigenic charge on the deposition of immune complexes (IC) in rabbit glomeruli. Acute serum sickness nephritis was induced by injecting chemically modified cationic bovine serum albumin (BSA). Controls were immunized with native BSA. After 14 days, 25 mg/rabbit of same types of BSA was challenged into each group. Renal biopsy was performed before and after the second injection. In the former biopsy, neither IC nor antigen was detected in the glomeruli. After the challenge, rabbits given cationic BSA developed the deposition of IC in the glomerular capillary walls, whereas no IC deposition was found in rabbits given native BSA. Next we analyzed the properties of IC composed of cationic BSA and its antibody. We observed that the group immunized with cationic BSA produced low avidity and low-non precipitating antibody. The levels of precipitating antibody and avidity values in this group were significantly lower than those in the group immunized with native BSA (p<0.001). The sucrose density gradient ultracentrif ugation study showed the size of IC in cationic group was nearly 7S. From the above results, we speculated that ; 1) The IC deposition on the glomerular basement membrane (GBM) results from circulating IC. 2) The IC composed of cationic BSA effectively binds to the polyanion layer of GBM. 3) Chemically modified cationization alters the immunogenicity of BSA, therefore causing the formation of small sized IC.
- 社団法人 日本腎臓学会の論文
社団法人 日本腎臓学会 | 論文
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