Determination of polyamines in plasma and erythrocytes of patients with chronic renal failure.
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The levels of putrescine, cadaverine, spermidine and spermine in uremic plasma and erythrocytes were determined by high performance liquid chromatography. All four polyamines in uremic plasma were higher in 28 patients with chronic renal failure (9 non-hemodialysis and 19 hemodialysis) than in 8 normal subjects. The mean values for both putrescine (p<0.002) and spermidine (p<0.006) were significantly higher than in normal subjects. putrescine (p<0.001) and spermidine (p<0.002) levels were significantly lowered by maintenance dialysis. Spermidine and cadaverine in uremic erythrocytes were significantly (p<0.05) higher in 10 patients than in 8 normal subjects. The erythrocyte polyamines were also measured in the patients before and after hemodialysis. The spermidine content was lowered but those of the other polyamines were not. There was a significant correlation between the level of putrescine in plasma and llematocrit in non-and hemodialysis patients group (r=-0.629, p<0.01). On the other hand, There was also a significant correlation between the level of spermidine in plasma and BUN in plasma (r=0.639, p<0.01). In the hemodialysis patient group, there was a significant correlation between the level of spermine in plasma and hematocrit (r=-0.385, p<0.05).
- 社団法人 日本腎臓学会の論文
社団法人 日本腎臓学会 | 論文
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