Natural killer activity in primary glomerular diseases.
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概要
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In order to clarify the role of cell-mediated immunity in primary glomerular diseases (PGD), we investigated natural killer (NK) activity by peripheral blood mononuclear cells (PBMC) against K 562 cells and the effect of the PGD sera on NK activity, and comparing to the sera of healthy volunteers. The patients studied included 10 cases of minimal change nephrotic syndrome (MCNS), 19 of IgA nephropathy (IgA-GN), 30 of non-IgA mesangial proliferative glomerulonephritis (non IgA-GN), 14 of membranous glomerulonephritis (MGN), 7 of membranoproliferative glomerulonephritis (MPGN), 2 of rapidly progressive glomerulonephritis (RPGN) and 100 of healthy volunteers as controls. NK activity in patients with nephrotic syndrome of MCNS, MGN and MPGN were significantly decreased compared to that of control group. On the contrary, there was no significant change in NK activity among patients with IgA-GN, non IgA-GN, RPGN, and non-nephrotic stage of MCNS, MGN and MPGN. When normdl PBMC were pretreated with PGD sera, the NK activity in only one case with MPGN was markedly decreased. The sera of other PGD and healthy volunteers did not exert a suppressive effect on NK activity. These data suggest that the deflect in NK cells is seen in patients with nephrotic syndrome of MCNS, MGN and MPGN, and the suppressed NK activity in MPGN can be ascribed to anti-NK cell specific inhibitor in MPGN sera. The deffect of NK cells racy be important in pathogenesis of PGD.
- 社団法人 日本腎臓学会の論文
社団法人 日本腎臓学会 | 論文
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