タイトル無し
スポンサーリンク
概要
- 論文の詳細を見る
Following the recent advancement in renal surgery, conservative operations tend to be often performed. And, ischemic renal surgery may be required in some of these cases. It is presumable that diseased kidneys are more vulnerable to ischemia than normal kidneys. Even the short ischemic time, generally considered harmless for normal kidneys, may be harmful for diseased kidneys. The experimental studies in female mongrel dogs were performed concerning the effects of ischema on the obstructed kidneys. Effects of 60 minutes warm ischemia on the normal kidneys were minimum. Mean Ccr of the experimental side four weeks later was 70.8% of control pre-ischemic value. Unilateral ureteral ligation for one week resulted in slight renal damage. Mean Ccr four weeks after release of obstruction was 79.9% of control. 60 minutes renal artery clamp were performed on the kidneys with ureteral ligation for one week, which resulted in severe renal damage and poor functional recovery after release of obstruction. Mean Ccr at four weeks after release was 12.4% of control. Moreover, V/GFR, FENa and FECa<SUP>++</SUP> of the experimental side after release were extremely high in this group. Histological examination revealed severe tubular damage with marked interstitial fibrosis. In another group, renal ischemia for 60 minutes with simple surface cooling were performed on the kidney with ureteral ligation for one week. Functional recovery were considerably after release of obstruction. Mean Ccr of the experimental side four weeks later was 63.6% of control value. Although, high V f GFR, FENa and FECa<SUP>++</SUP> were also shown in this group. The results indicate that, although the obstructed kidneys are more vulnerable to ischemia, even the short ischemic time, renal cooling seems to be valuable. Surgical intervention on such diseased kidneys will need care to prevent significant hemodynamic alterations.
- 社団法人 日本腎臓学会の論文
社団法人 日本腎臓学会 | 論文
- Henoch-Schoenlein purpura nephritis in a patient infected with the human immunodeficiency virus
- Responses of Renin-Angiotensin-Aldosterone System to Insulin Hypoglycemia in Patients with Essential Hypertension
- A case of hypocomplementemic mesangial proliferative glomerulonephritis progressing to focal membranoproliferation without aggravation of urinalysis.
- Low serum aminotransferase activity in patients undergoing regular hemodialysis.
- Membranoproliferative glomerulonephritis-like lesion with fibrillary deposition associated with multicentric Castleman's disease.