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It is well known that fibrin-fibrinogen degradation products (FDP) appear in the urine of patients with renal disease. To clarify the mechanism of urinary FDP excretion, FDP in blood (defibrinated plasma) and urine taken from patients with various renal diseases was isolated by SDS-polyacrylamide gel electrophoresis.<BR> The resluts were as follows :<BR>1) Fragment D-dimer was found in the blood in 18 of 89 cases (20.2%) and in the urine in 22 of 59 cases (37.2%). It may be supposed that there was clotting and fibrinolysis in the blood or the urine in the patients with positive blood or urinary D-dimer. However it could not be proved that there was intra-glomerular coagulation in these patients.<BR>2) Cases with positive blood or urinary D-dimer had severe glomerular lesions, renal dysfunction and high levels of microhematuria in comparison with cases with negative blood or urinary D-dimer.<BR>3) No correlation was recognized between D-dimer and FDP levels in blood or urine specimens.<BR>4) There was no correlation between urinary D-dimer and urinary protein. Neverthless, the ratio of urinary FDP to urinary protein in D-dimer positive cases was higher than in D-dimer negative cases.<BR>5) Fragment D-dimer in urine was only a small amount of total urinary FDP. Therefore it may be suggested that urinary FDP excretion is associated with the filtration of plasma fibrinogen and blood FDP to urine through the glomerular basement membrane. And in patients with a higher ratio (X+Y/D+E) of urine FDP than blood FDP, filtration of plasma fibrinogen appeared to be major factor in the excretion of urinary FDP.
- 社団法人 日本腎臓学会の論文
社団法人 日本腎臓学会 | 論文
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