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Forty-nine patients with lupus nephritis out of the 74 with systemic lupus erythematosus (SLE) followed for an average of 9 years since 1962 were investigated to clarify the longterm outcome and the factors modifying their prognoses. Five year suvival rate of whole SLE patients and those with lupus nephritis were 82 and 84 per cent, and 71 and 66 per cent at 10 years from the onset of clinical manifestations, respectively. Sixteen patients with lupus nephritis and 5 without were dead during the follow-up period. The former included only 2 renal deaths and all 5 deaths in the latter occurred within initial 5 years from an apparent onset. As for outcome of renal function, no relationship with initial glomerular histology was observed, mainly because of possible histologic transformations as observed in 7 of 17 patients. Analyses using a life-table method regarding prognostic indices for lupus nephritis appeared that sex, age at onset and the complication of nephrotic syndrome did not significantly participate in their survival, but hypertension seemed to make them worse. In summary, (i) the lupus nephritis might suggest to appear a life-threatening complication in SLE patients, however, it was rare that a patient died of lupus nephritis itself. (ii) It seemed difficult to make an accurate estimation of long-term outcome in lupus nephritis and SLE from renal histology.
社団法人日本腎臓学会の論文