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In order to evaluate the correlation between the size of CIC and glomerular histology, sera with positive CIC from 6 patients with lupus nephritis were fractionated by sepharose C. L. 6B column chromatography. The fraction thus obtained were divided into three groups and expressed as small (M.W. equivalent or less than IgG), middle (M. W. between IgG and IgM) and large (M. W. between void volume and IgM) size. The CIC activity of each fraction was examined by Raji cell IF assay. The CIC activity in patients with severe diffuse proliferative LN was found mainly in the fraction of middle and large size, whereas the activity in three patients with mesangial proliferative LN was found exclusively in the fraction of small size. As a control study, the size of CIC in patients with non renal SLE (2 cases), SLE+RA (2 cases) and RA (2 cases) were also examined and the CIC activity was only found in the fraction of small size in all cases. It was concluded that CIC size in patients with LN had a definite correlation to the glomerular histology and the determination of CIC size was valuable for the analysis of pathogenesis and prognostic index in patients with LN.
- 社団法人 日本腎臓学会の論文
社団法人 日本腎臓学会 | 論文
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