The effect of Gentamicin and mercuric chloride on cyclic AMP and lipoperoxide in rat kidneys.
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In order to elucidate the nature of nephrotoxicity induced by gentamicin and mercuric chloride, morphological and biochemical experiments were performed in rats. The main histological change in gentamicin treated rats was presence of many myelin-like structures in the cytoplasm of the proximal tubular cell. On the other hand, examination of kidneys from rats receiving mercuric chloride revealed many vacuoles in the same location, No marked changes were observed in the plasma membrane and the membranes of organelles, In biochemical study, however, renal tissue concentration of cyclic AMP was decreased, while that of lipoperoxide was increased. These facts suggest that those nephrotoxic substances might attack both the membranes of cellular organelles and the cell surface after their accumulation in organelles, since production of cyclic AMP is dependent upon the activity of adenyl cyclase in cell surface membrane and lipoperoxide is mainly produced from phospholipids present in the endocellular and cell surface membranes.
- 社団法人 日本腎臓学会の論文
社団法人 日本腎臓学会 | 論文
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