Studies on the Effect of Protamine on the Aminonucleoside Nephropathy in Rats:-A trial to Produce an Experimental Focal Glomerular Sclerosis-
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The effect of the systemic administration of protamine sulfate (P), a polycation substance, and aminonucleoside (AN) of puromycin has been studied as a trial to produce an experimental model of focal glomerular sclerosis. Eleven male Sprague-Dawley rats received P, 4.5mg/100g BW/day i. v. for 7 days simultaneously with subcutaneous injection of AN 1 mg/100g BW/day. One of the animals was sacrificed 8, 9 and 10 days after the beginning of the administration, and other 8, 3 months after (Group AN+P). Control groups were prepared as follows; (1) i. v. injection of P for 7 days before the treatment of AN (2) i.v. injection of P for 7 days after the treatment of AN (3) i, v. injection of sodium heparin (H) 450U/ 100g BW/day simultaneous with AN+P (5) subcutaneous AN and i, v. H (5) subcutaneous AN and 0.9% saline (S) i. v. (6) subcutaneous S and i. v. P (7) subcutaneous S and i, v. S. Ten days after the initial AN administration, animals of the group AN+P showed a great increase in urinary protein (UP) (mean±SD ; 478±95mg/1000min), and severe nephrotic state with ascites. UP in the group AN+P was significantly higher than in control groups at that time and 3 months later as well (mean±SD ; 45±32), when UP in the AN-administered control groups (1) to (5) recovered to the basal value. At that time there was observed a significantly larger number of sclerotic glomeruli with hyaline deposits (mean±SD; 24.2±11.3%) in the group AN+P than in the control groups. These results suggest that the additional administration of P with AN may induce severer polyanion loss in glomeruli than the single treatment of AN and that the consequent irreversible damage in protein permeability may lead to focal sclerotic lesions.
- 社団法人 日本腎臓学会の論文
社団法人 日本腎臓学会 | 論文
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