Fibrinogen (Fibrin), Factor VIII and Factor XIII in Children with Various Renal Disease
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概要
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Renal biopsy was performed on a total of 22 children including, 7 cases with acute glo- merulonephritis (A.G.N.), 6 with nephrotic syndrome (N.S.) and 9 with purpura nephritis (P.N.), and histological findings and depositions of fibrin (Fb), factor VIII-related antigen (VIIIR : AG), factor XIII subunit A (XIII. A) or factor XIII subunit S (XIII. S) in the glomerular lesion, were investigated in comparison with levels of fibrinogen (Fg), factor VIII and XIII in blood. In the acute stage of A.G.N., there was observed same evidence of mild glomerular capillary Fb. deposition, a companying deposition of VIIIR : AG, XIII A or XIII S, but depositions of VIII: AG and XIII A could not be found in the recovery or persistent stage. At the relapse phase of N.S., level of Fg., factor VIII and XIII in blood were elevated. But glomerular deposits of the coagulant factors were not detected in the cases with minimal change or mild proliferative lesion. On the other hand, intense depositions of Fb. and mild depositions of VIIIR : AG, XIIIR : AG, XIII A or XIII S were observed in the glomerular capillaries or mesangium area in nephritic nephrosis or frequent relapser. In P. N., there was seen an increased level of Fg. and a decreased level of factor XIII especially in the cases including severe proliferative glome rular lesion with crescent formation. In these cases, intense and dense deposit of Fb. was seen in glo merular capillaries and crescent, togather with mild to moderate deposition of VIIIR : AG, XIII A or XIII S in glomerular capillalies.
- 社団法人 日本腎臓学会の論文
社団法人 日本腎臓学会 | 論文
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