Brain Check-up and Climacteric-Age-related Study of Brain Check-up in Japanese Women-:—Age-related Study of Brain Check-up in Japanese Women—

概要

論文の詳細を見る
The survival of Japanese women is prolonged and the mean life span is approximately 85-year-old. Early management of disorders related to daily life style, including obesity, hypertension, hyperlipidemia and diabetes mellitus, contributes to prevention of ischemic heart diseases and stroke in older women. In a total of 2, 443 healthy women who had the first brain check-up, we studied age-related changes of cardiovascular risk factors, brain magnetic resonance imaging and angiography. Subjects were divided to four groups: the pre-menopausal group (age≤44 years), the climacteric group (age 45-54 years), the pre-senile group (age 55-64 years) and the senile group (age≥65 years) . In age-adjusted logistic regression analysis, an increase of body mass index, blood pressure, fasting blood sugar levels, serum total cholesterol levels, serum LDL-cholesterol levels or serum triglyceride levels, and a decrease of serum HDL-cholesterol levels were significantly correlated with prevalence of asymptomatic lacunar infarction and progression of cerebral aherosclerosis. Thus, such cardiovascular risk profile should be monitored from an early period of climacteric. Appropriate treatment with those risk factors could prevent event of ischemic stroke in elderly women.
一般社団法人日本総合健診医学会の論文