Cautions in Evaluation of Serum LDL-cholesterol-Methods of Measurement and the Meal in the Previous Night-:—Methods of Measurement and the Meal in the Previous Night—

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• To obtain serum LDL-cholesterol concentrations, an indirect method in which the value is derived by calculation using Friedewald formula (LDL-cholesterol=Total cholesterol-HDL-cholesterol-1/5 of triacylglycerol values) has been accepted because direct measurement of LDL-cholesterol needs relatively complicated procedure. Although it contains a potential error in individual with high triacylglycerol, many health care institutions still use the indirect method. As a relatively simple direct method has been developed recently, we examined the deviation of the value obtained by the indirect method even in individuals with normal triacylglycerol levels to encourage the institutions to use the direct method. The influence of a meal taken in the previous night was also evaluated, since serum lipids levels change by energy of previous meal. In healthy 35 volunteers three kinds of experimental meals of previous night were tested. The three meals contained high-energy (1, 011 kca<I>l</I>), standard-energy (658 kca<I>l</I>, control), and noenergy, respectively and the study was performed with one-week interval. Blood samples were taken in the next morning at fasted state and serum lipids and glucose levels were measured. There were no significant changes in triacylglycerol, total-cholesterol, and HDL-cholesterol concentrations among three meals. However, LDL-cholesterol concentrations measured with the direct method significantly increased after the no-energy meal. Glucose levels were decreased after the no-energy one. On the contrary LDL-cholesterol levels calculated with the indirect method were not changed after the no-energy one and decreased after the high-energy one. These results suggest that health care institutions should adopt the direct method to measure LDL-cholesterol concentrations and emphasize the importance of a standard-energy meal in the previous night.

• 一般社団法人 日本総合健診医学会の論文

一般社団法人 日本総合健診医学会 | 論文

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