Effects of Cigarette Smoking on the Personal Exposure to Mutagens in Air.
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概要
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Effects of cigarette smoking on the personal exposure to mutagens in air were demonstrated. Airborne particulate and gaseous samples were collected by filters and adsorbent tubes with mini pump for 24 hours. Urine samples were also collected simultaneously for 24 hours. The concentrations of nicotine and 7 polycyclic aromatic hydrocarbons (PAHs) in personal exposure air samples were determined with GC/MS analysis and with HPLC/spectrofluorometric analysis, respectively. The mutagenicity of airborne particulate samples were assayed with <I>Salmonella typhimurium</I> strain TM677 in the absence of S9mix. The concentrations of nicotine and its metabolite cotinine in urine samples were determined with GC/MS analysis. The mutagenicity of Sep-Pak tC<SUB>18</SUB> extracts for urine samples were assayed with <I>Salmonella typhimurium</I> strains TA100, TA98 and YG1024 in the presence and absence of S9mix.<BR>The concentration of nicotine in personal exposure air showed good correlations with the mutagenicity of personal exposure air, with the concentration of cotinine in urine and with the mutagenicities of urine, especially in the presence of S9mix. The correlation of the urinary mutagenicity with the concentration of pyrene in the air were better than those with other PAHs in the air. Also a good correlation was obtained between the concentration of cotinine in urine and the mutagenicities of urine, however their correlations were decreased in the case of non-smokers'.
- 日本環境化学会の論文
日本環境化学会 | 論文
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